Sometimes, behind a strong anime protagonist, is a sister who has their back. Whether they’re related by blood or not, what matters is the bond they have. They protect their siblings, friends, and/or sibling figures fiercely and sometimes aren’t afraid to tell them off to keep them on the right track.
What matters the most is that these anime sisters are just so lovable, even when they’re being scary. They are always looking out for their siblings' well-being and will help them in any way they can. Their siblings and friends love them for being in their lives, and fans love them because of their personalities and strength, and because they’re just overall amazing sisters.
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Updated March 6, 2025, by C.M. Edwards: A vital aspect of any anime series is the characters. Strong bonds between these characters and the viewers allow connections and allow fans to relate to the series on a deeper level. When these characters share bonds such as friendship and loyalty, fans enjoy the camaraderie and the dynamic these characters present. Family is always the most important thing, and often, it comes down to the brother-sister duo in anime who are on their own and must do their best to protect themselves and each other. Sisters in anime are usually dependable siblings, able to pull their family out of the fire whenever they are in need. Here are some more of the most lovable anime sisters in anime.
21 Kei Shirogane
Kaguya-Sama: Love Is War
- First Appearance: Episode 6
Kei Shirogane is the younger sister of one of the main characters of Kaguya-Sama: Love Is War, Miyuki Shirogane. Kei is a rambunctious ball of fire, much like her older brother. However, in public, she retains a classy and princess-like demeanor, almost mimicking her brother.
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Kei is a dedicated little sister who holds a deep stake in her brother's appearance and love life. She goes out of her way to make sure he doesn't do anything to embarrass her or himself. A hard worker and incredibly socially mature, Kei is a dependable young woman who is good to her friends and wants the best for others.
20 Tamari Nara
Naruto
- First Appearance: Episode 20
Tamari first appeared in Naruto as an antagonist belonging to the Village hidden in the Sand. However, Tamari's story and standing in Naruto would evolve significantly as she became the wife of Shikamaru Nara and a permanent resident in Konoha.
Tamari is the sister of Gaara and Kankuro, and the elder sibling of the bunch. As a proud and dedicated ninja, Tamari was a great fighter on the battlefield. Additionally, she was a level-headed person outside of battle with a great amount of maturity and responsibility. This stems from her mother's death when she was young after having Gaara. Tamari is an unshakable well of strength that all close to her can depend on.
19 Kaeda
Rascal Does Not Dream Of Bunny Girl Senpai
- First Appearance: Episode 1
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Kaeda is the younger sister of the main character, Sakuta, whose experience with adolescence syndrome leaves her amnesiac after being severely bullied. She adopted the personality of Kaeda, a sweet and innocent but naive young girl who is too scared to venture outside and is entirely dependent on her older brother. Kaeda's tragic circumstances nearly outweigh her heartbreaking recovery in the series, but she remains one of the most lovable sisters in anime.
18 Karin Kurosaki
Bleach
- First Appearance: Episode 1
Karin is the youngest of the Kurosaki family, and unlike her family, she is a much more reserved character who keeps a cool head most of the time. During the majority of the Bleach series, it is seemingly alluded to that Ichigo's family is unaware of his soul-reaper activities.
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However, Karin is one who is aware of spiritual presence and the presence of hollows. Karin is the binding that keeps her family together. She is very mindful of their stress levels and emotional state. She tries her best to ensure her family is happy and healthy, especially her big sister.
17 Inui Shinju
My Dress-Up Darling
- First Appearance: Episode 7
Shinju is the younger sister of Sajuna in My Dress-Up Darling. She is first introduced in episode seven of the series and is much the polar opposite of her big sister. Shinju is a very soft-spoken girl with a clumsy demeanor and serves as the photographer for Sajuna's cosplay photoshoots. Shinju idolizes her big sister and wants nothing more than to see her continue to be more successful. Its Shinju's love for her big sister that makes her such a sweet character.
16 Shiro
No Game No Life
- First Appearance: Episode 1
Shiro is a bit of a dark horse but makes up for her personality with her intellect. In No Game No Life, Shiro is a genius who excels in strategy and tactical thinking, which serves her well when taking on the god of games, Thet.
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Shiro has a somewhat cold and dry personality that usually rubs others the wrong way, which is why she is so close to her brother, the only one who accepts her as she is. With all her skill and intelligence, Shiro is unable to function without her brother, Sora, due to her abandonment issues from her mother.
15 Maki Zenin
Jujutsu Kaisen
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- First Appearance: Season 1 Episode 5
Maki and her sister Mai are on horrible terms, but there’s a lot of family history behind it. However, Maki is very much like an older sister figure to the underclassmen and to some of the other classmates regardless of their age. Though a bit cold and sometimes impatient, Maki still helps her underclassmen train hard because she genuinely wants them to get stronger. She was even hard on Yuta, who was in the same grade as her because she wanted to get stronger and fight beside her.
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Her classmates greatly respect her on and off the battlefield. Nobara had told Yuji they had to win the Goodwill Event because they had to help Maki prove the Zenin wrong. Maki was initially annoyed by this but was touched by this.
14 Shizuru Kuwabara
Yu Yu Hakusho
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- First Appearance: Episode 1
She might not be the most lovable sister to her brother, but Shizuru has shown that she cares about Kazuma and his overall well-being. She supported Team Urameshi throughout the Dark Tournament along with Botan, Yukina, and Keiko. Plus, she showed that she’s not someone to mess with and beat up a couple of low-level demons by herself. Shizuru is highly critical of her brother and isn’t afraid to be harsh if he does badly in anything. Even though he’s clearly stronger, Kuwabara is shown to be afraid of her when she gets mad at him.
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Shizuru also doesn’t just care about Kuwabara’s physical well-being, but also his future. She strongly advocated for her brother to focus more on his education and not go to the Demon World because it’s not his fight or problem. Kuwabara decides to listen to her advice and retires from fighting to live a normal life, not wanting to fight demons for the rest of it.
13 Yor Forger
Spy X Family
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- First Appearance: Season 1 Episode 2
She might be an assassin with a deadly set of skills, but Yor truly loves her family. In order to give her younger brother Yuri a better life, Yor joined Garden (an assassination group) to provide for him. She took up a parental role in his life and has gone to extreme measures to take care of him.
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When Yuri was sick, Yor went to the forest to collect herbs, got stung by bees, and killed a boar. Though her occupation is dark and bloody, Yori is very protective of her family and truly loves them with all her heart.
12 Saeko Tanaka
Haikyuu!!
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- First Appearance: Season 2 Episode 2
Much like her younger brother Ryunosuke, Saeko is loud and confident. She’s a little rough around the edges and is more of a “tough love” kind of sister. However, she and her brother have a close relationship and usually have the same chaotic energy to match. Ryunosuke does get embarrassed at times by Saeko’s antics, but he knows he can always count on her to help when he needs it.
She was willing to help him bring Kageyama and Hinata to Tokyo when they needed a ride. She would show up to games and loudly cheer on Karasuno even though her brother would tell her to take it down a notch. But it was very heartwarming to see Saeko bring a taiko drum group to cheer on Karasuno during their match against Shiratorizawa.