Bethesda Game Studios' Fallout 4 is a vast open-world game in a post-apocalyptic world filled with interesting content for players to explore. Set in the ruins of Boston following a worldwide nuclear war, players will be tasked with surviving, rebuilding, and shaping the future of civilization as they go, interacting with a range of interesting characters and facing deadly enemies. In addition to the myriad main and side quests available for players to complete, there are also extensive crafting systems for weapons and armor and a settlement management system that enables players to construct their own post-apocalyptic communities across various locations in the game world.

Originally released in 2015, Fallout 4 has remained one of Bethesda's most popular titles, offering hundreds of hours of gameplay and various content-rich DLC and updates that have added new quests and items. With so much content for players to explore, it can be challenging to navigate the game's various aspects or to find specific rare items among so much in-game loot. The following Fallout 4 guide will help players navigate the different areas of the game and highlight the locations of important items and the methods of achieving certain objectives or desired builds.