Although there are many ways a teenager might be summoned to another world, one of the most common routes goes through gods (or goddesses). Quite frequently, an isekai anime and manga gets things going by killing off the protagonist and dropping them in front of a deity, who tends to apologize for the early death and then promises to set them up for a cushy new life. Occasionally, truck-kun is not called into action, as the gods opt to summon the MC directly, teleporting them into a new world that needs their help. Usually, this interaction is a positive and fruitful one. However, once in a blue moon, the god absolutely despises the isekai protagonist.

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When this dynamic is established, the god or goddess is typically presented as the story's main villain, even if they might not appear all that often after that point. They usually set the protagonist up to fail or straight-up die, only to have their arrogance thrown in their face when their victim becomes the most powerful person to ever exist. At that point, revenge might be on the cards.

Saga of Tanya the Evil has been omitted since, well, Tanya does not recognize Being X as a god.

5 Tsukimichi: Moonlith Fantasy

Cursed By The Goddess For Being "Ugly"

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Tsukimichi: Moonlit Fantasy
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Release Date
2021 - 2024
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WHERE TO WATCH

Streaming
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Japanese Title
Tsuki ga Michibiku Isekai Douchuu
Studio
C2C, J.C.Staff
Based On
Light Novel
Creator(s)
Kei Azumi
Streaming Service(s)
Crunchyroll

Tsukimichi is a great manga series, and believe it or not, better than its anime version. From the get-go, the protagonist is marked as "ugly" by the very deity that summoned him and his companions to another world. Then, he is sent to die in the middle of the desert (aka the monster Realm).

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The goddess went even further by cursing the MC, prohibiting him from learning the human language of that world, so he could only communicate using floating text magic. That is, with humans, of course, since he has gained the blessing of the rejected gods, he can talk to monsters, and he decides to create a paradise for those despised for being ugly: orcs, goblins, and other fantastical beings. It's a story about resilience, perseverance, and cool combat scenes.

4 Failure Frame

Discarded And Sent To Die By The Goddess

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Failure Frame: I Became the Strongest and Annihilated Everything with Low-Level Spells
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Release Date
2024 - 2024
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Studio
Seven Arcs
Number of Episodes
12
Japanese Title
Hazurewaku no "Joutai Ijou Skill" de Saikyou ni Natta Ore ga Subete wo Juurin suru made

One of the things about the isekai genre is that once in a while comes a series that is really interesting but its anime doesn't do it justice. Such is the case of Failure Frame, another good series that is better in the manga (and the novels) but loses in quality when animated.

A story about revenge against a goddess that is so cruel and malevolent that she has her own dungeon to feed monsters with those she deems "unworthy" of her blessings. A manipulative, vindictive, and dangerous deity that has a lot of dark secrets, and is probably to blame for all the problems of her world.

3 Mushoku Tensei

A Manipulative God Will Do Anything To Ruin His Family

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Mushoku Tensei Jobless Reincarnation
Mushoku Tensei: Jobless Reincarnation
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Release Date
January 11, 2021
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Studio
Studio Bind
Creator
Rifujin na Magonote
Number of Episodes
48
Japanese Title
Mushoku Tensei: Isekai Ittara Honki Dasu

The world of Mushoku Tensei: Jobless Reincarnation is filled to the brim with larger-than-life foes that can make the lives of its heroes quite miserable. But among all the dangerous foes Rudeus and his "extended family" will be facing in this adventure, Hitogami is perhaps the most dangerous and vile of them all.

The very same god that summoned Rudeus to this fantastical world is the manipulative being who is trying to prevent certain members of his family from being born. A twisted and ruthless creature, whose evil plans are known to those who have read the novels (but we will avoid mentioning them to prevent spoilers for those who only watch the anime). So yes, this anime has a god that hates its main character, or at least despises what he represents and what his legacy can become: a hindrance to his plans.

2 The World's Finest Assassin Gets Reincarnated In Another World As An Aristocrat

He Didn't Get So Far By Being Naive

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The World's Finest Assassin Gets Reincarnated in Another World as an Aristocrat
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Animation
Action & Adventure
Sci-Fi & Fantasy
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Release Date
2021 - 2021-00-00
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Seasons
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An intense take on the isekai genre, where an assassin (the world's strongest and most skilled one) is sent to a fantasy-like world to reincarnate as the scion of a noble family who (drum rolls) handles political assassinations, no less. In the wake of his transcendence to this new world, he meets the goddess of this realm, and as he retains all his memories from his past life, he won't trust anything this being says.

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Though the anime doesn't quite clarify that Lugh is cautious of the goddess' schemes, the manga (and the novel) allow readers to tap into his inner thoughts and plans, and one of them consists of finding a way to avoid falling into the tricks of fate planned by the deity. It all points to this divine trickster throwing Lugh into this world for some obscure purpose, and the MC will need all his wits to prevent falling into her trap.

1 The Hero Is Overpowered But Overly Cautious

Ristarte Hates Seiya And His Attitude, But A Dark Twists Awaits Ahead

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Cautious Hero The Hero Is Overpowered but Overly Cautious
Cautious Hero: The Hero Is Overpowered but Overly Cautious
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Release Date
October 2, 2019
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Studio
White Fox
Creator
Light Tuchihi
Number of Episodes
12
Japanese Title
Shinchou Yuusha: Kono Yuusha ga Ore Tueee Kuse ni Shinchou Sugiru

With a high dose of humor and a main character who is ridiculously strong and still finds a way to train every second he can, this series is about a young goddess trying to lead the world to a "good ending" with the help of a quirky and powerful summoned hero. Ristarte hates Seiya's attitude, and she constantly remarks how much she regrets summoning him. At some point, it is made clear that their relationship couldn't be worse since Seiya practically uses her as a "time stop" button to do as he pleases.

Rude and stubborn, this hero will do anything to win, even if he has to train himself way beyond the limits of the gods, and is nothing but a nuisance in the eyes of the deity that summoned him. But what she doesn't know is that there's a deep and dark reason for Seiya to be this way and that they share more than the common goal of defeating the Demon Lord. All will be revealed on time, and the twist will be so heartbreaking that the fans will never know what hit them.

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