Fallout 4: The Most Powerful Enemies, Ranked

Once the sole survivor defrosts from their 200 years of sleep and awakens to a post-apocalyptic nuclear reality in Fallout 4, they'll be forced to traverse the harsh and frightening wastelands that stretch before them. Littered with clues about what they've missed, abandoned houses, raider outposts, and even small settlements of hope, they're likely to also come across the diverse cast of horrible monsters and powerful enemies lurking in the radiation-riddled hills and forests.

Although many of these creatures are relatively easy to deal with, there are a select few that make even the most seasoned player tremble in their Vault jumpsuit. Players need to pull out their best weapons to deal with some of the strongest enemies in Fallout 4, which is easier said than done at low levels when a single attack from these dangerous foes can one-shot players and force them to circumvent this challenge until they're ready to tackle such a powerful enemy.

Updated on July 19th, 2024, by Ritwik Mitra: The Fallout series has consistently been at the forefront of the gaming mainstream, so fans of the series were more than glad to see that the success of Amazon's TV adaptation meant that more players would get into this amazing post-apocalyptic RPG series and see why so many fans hold this game in high regard. The latest game in the series, Fallout 4, enjoyed a next-gen patch to accompany the release of the TV series that has become more stable after being derided by many fans. The game is a blast to play through as players journey across the Commonwealth and take on a bunch of foes, some of which are the strongest enemies in Fallout 4 and will give them a ton of problems to deal with.

24 Glowing Bloodworm

The Strongest Variant Of The Burrowing Bloodworm

• Location: In and around the Nuka-World amusement park
• Health: 230

Any enemy that burrows into the ground is a pain to deal with, and the accursed Bloodworms are no exception to this golden rule. These enemies attack a pack, making VATS the only reliable way to target them.

The toughest variant of this enemy attacks in hordes and can overwhelm players if they don't take out these foes from a distance. If players get mobbed, then they can be on the receiving end of a rather humiliating death.

Pro Tip: VATS Helps Players Locate Where These Creatures Are When They Burrow Into The Ground

Bloodworms confuse players by obscuring their vision whenever they burrow underground. If players don't want to be ambushed by a horde of these enemies, then using VATS to locate them is the best course of action to take.

23 Raiders With Fat Men

Glass Cannons Who Can Nuke Players Into Oblivion With A Single Shot

• Location: Almost anywhere in the Commonwealth
• Health: Over 45 (increases with the Sole Survivor's level)

Raiders are pretty run-of-the-mill fodder in Fallout 4, with players mowing down hundreds of these foes as they go through the game. While these enemies scale up along with the Sole Survivor's level, that still doesn't stop them from being pretty weak and easy to take out in a few shots, especially if the player has a powerful weapon. However, there is one exception here, and that's when one of these raiders has the gall to whip out a Fat Man in battle.

This weapon will obviously kill players in one shot, making it the need of the hour to take them out before they can unleash a shot from this powerful mini-nuke launcher. As iconic as this weapon may be, it's frustrating to be taken out in a single shot and not be able to do anything about it. As a result, any raider with a Fat Man becomes one of the most dangerous glass cannons in the game.

Pro Tip: Prioritize These Enemies And Take Them Out Quickly

There's no point in taking cover against these enemies. Players should just rush them from the get-go and pray that they can take down this enemy before it unleashes a powerful nuke.

22 Nukalurk Hunter

A Souped-Up Version Of A Mirelurk

• Location: In various areas in Nuka-World
• Health: 470

Mirelurk hunters love to hunt down their enemies, and their Nukalurk brethren are no exception to this golden rule. The unique hue they emit makes these enemies look even more intimidating.

If players attract the attention of these enemies, then it's important to take them down as soon as possible before they pose a serious problem. Nukalurks will mob the Sole Survivor if they're too indecisive about taking these mutated lobsters out.

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Pro Tip: Ranged Combat With Powerful Guns Is The Way To Go

While their spit does decent damage, Nukalurk hunters are deadly if players let them close the distance. This makes it important for the Sole Survivor to keep their distance if they don't want to be diced up by these damaging claws.

21 Radscorpion Predator

A Mutated Monster Who Can Rip Players Apart At Close Range

• Location: The Commonwealth, The Glowing Sea, and Nuka-World
• Health: 950

Radscorpions are some of the scariest enemies in the Fallout series. An encounter with this monster at earlier levels will lead to a player's doom as they get clawed and stabbed to death in no time.

The Radscorpion Predator has as much HP as a Behemoth, making it one of the toughest enemies to deal with. Players must keep their distance to ensure that they aren't killed in record time by these fearsome predators.

Pro Tip: Stay Out Of Melee Range At All Costs

Radscorpion Predators do serious damage from up close, no matter how strong players are. It's imperative to keep one's distance and not get too overzealous while attacking these foes.

20 Enraged Fog Crawler

A Mutated Monster Who Can Rip Players Apart At Close Range

• Location: Mount Desert Island
• Health: Over 2200

Found in the Far Harbor DLC, this giant shrimp and lobster hybrid (with a hint of grasshopper in it as well) is one of the brand-new terrors players are faced with on Far Harbor island. There's even a quest that sends players to slay one of these early on in the DLC.

The Fog Crawler is big and strong but is easily dealt with at a distance. The enraged variant, however, has much more health and strength overall, making it the worst variant to fight in the wild.

Pro Tip: Use Energy Weapons Or Armor Piercing Weapons

The Enraged Fog Crawler has very high damage resistance, which means it can take a long while to chip away at its health. It's a good idea to have a leveled-up energy weapon or at least a companion with a dedicated energy weapon to laser them down. The enraged variant is also immune to the Wasteland Whisperer perk, so players shouldn't attempt to tame it unless they have a death wish.

19 Venomous Angler

Sneaky Monsters Who Catch Players By Surprise And Are Always At The Player's Level

• Location: Mount Desert Island
• Health: 1750

Another monster lurking on the foggy island of Far Harbor, the Angler is first encountered after arriving in Far Harbor when the town is attacked by a bunch of them. The creepy thing about these critters is their ability to camouflage in the mist, which is complemented by the glowing antenna that imitates the lure weed that can be harvested on the island.

There's nothing worse than approaching a swampland to get lure weed only to run into a whole group of these awful toad-like beasts. Their venomous variant is dangerous since they can't be tamed with the Wasteland Whisperer perk and they always match the player's level.

Pro Tip: Use Ballistic Or Melee Weapons To Exploit Their Weakness

Venomous Anglers are resistant to energy weapons, so it's better to stick to regular ballistic weapons instead. A melee weapon also does the trick, although most people would prefer to maintain their distance from this powerful enemy.

18 Super Mutant Warlord

The Toughest Variant Of A Super Mutant Enemy

• Location: Almost anywhere in the Commonwealth
• Health: Over 1535

The Super Mutant Warlord is the most powerful variant of this enemy that players can encounter in Fallout 4. For what it's worth, this enemy appears when players are at a high level, meaning that the Sole Survivor should be strong enough to take out this enemy as long as they're diligent in combat.

However, that doesn't mean that they should take a Super Mutant Warlord lightly. They hit like a truck, especially if they're kitted out with damaging weapons. These enemies can take a lot of shots before going down, so the player should make it a point to hit them with the most powerful firearms they can muster if they don't want to deal with an unnecessarily protracted confrontation.

Pro Tip: Use The Strongest Weapons Possible To Take Them Down

Sometimes, the best strategy is a simple one. Unloading the most powerful weapons against this foe is the best way to take them out before things become too harrowing.

17 Deathskull Radscorpion

Massive Scorpions Who Can Burrow Into The Ground And Deal Radiation Damage

• Location: Most commonly in the Glowing Sea
• Health: For Deathskull variants, over 1115

Radscorpions might seem like a generic and boring part of the bestiary for so many players, but they rank higher simply because they're a headache throughout the entirety of the game, regardless of where the player might be — from the northern forests to even the Glowing Sea.

They're very tough, and with the ability to move underground, they can ambush the player easily. At close range, they're deadly enemies that are able to deal quite a bit of radiation damage. The Deathskull variant is the one players will want to avoid the most.

Pro Tip: Dealing With Them From Afar Is The Best Way To Avoid Their Attacks

Radscorpions are no joke. They can close the distance in no time flat and sting an enemy until they're toast. It's better that players maintain a distance and use powerful weapons to take out this foe before things get too hot to handle.

16 Nukalurk King

The Toughest Variant Of The Mirelurk Enemy

• Location: Nuka-World's World of Refreshment
• Health: 500

Mirelurks, even with their queen, sometimes feel like a lost opportunity. That is, until players fight the Mirelurk King (and more specifically their Nukalurk variant, which can be met in the Nuka-Cola Bottling Plant in the Nuka-World DLC.

Even without the DLC, however, these beasts can be very scary in groups when they assault the player. They're able to attack players from afar and dish out quite a bit of damage at once due to their ranged sonar attack.

Pro Tip: Adapt To The Creature's Versatility And Unleash As Many Powerful Attacks As Possible

The Nukalurk King excels in both ranged and melee attacks. It's important to adapt to the creature's versatility and heal at regular intervals, especially if players are being mobbed by a group of these powerful foes.

15 Nukatron Sentinel

Mechanical Enemies Who Are Dangerous In A Group

• Location: Nuka-World's Galactic Zone
• Health: 420

The old Protectrons are nothing to be afraid of. They're just a bit tanky and take some time to deal with. However, once players meet the Nukatron Sentinel, they'll always have a small, permanent trauma lingering in the back of their head from being blasted with turquoise Nuka-Cola nuke juice.

The Nukatron Sentinel is a particular variant of the Nukatrons found in Nuka-World's Galactic Zone. They can be easy to bypass due to looking like tiny Nuka-Cola machines, but when they gang up on the player that's when it gets serious.

Pro Tip: Blast Them With Bullets And Explosives Before They Can Overwhelm The Player

Going on the offensive is important against these enemies, especially if they arrive in a group. Using AoE damage to take out multiple Nukatron Sentinels at once is a great way to take out these foes without facing too many problems.