Best RE4 Remake Loadouts for Extra Challenge

Summary

Costume builds in RE4 remake add replay value.
Builds like Hunter's & Classic offer unique challenges like beating the game using only original weapons.
The Untouchables build makes players invincible, thanks to two special items.

The Resident Evil 4 remake offers a surprisingly high level of replayability. With its New Game Plus mode and unlockable higher difficulties, the remake lets the fanbase enjoy this masterpiece repeatedly without boredom. However, there’s another way to enhance the replay value without relying solely on these game modes: using costume builds.

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With a diverse arsenal of weapons, the Resident Evil 4 remake encourages players to create unique loadouts. These setups can either ramp up the challenge or make gameplay easier, providing players with yet another reason to explore the fantastic campaign. Below are the top examples of such builds.

9 The Hunter’s Build

Hunt Down the Ganado from Afar

Items in the Build: The Punisher (handgun), The SR M1903 (sniper rifle)
The Challenge: Getting precision kills.

Accuracy has long been a key stat in the Resident Evil series. In Resident Evil 4 and its remake, for instance, players can view their precision level at the end of each chapter, showing how often their shots hit the mark versus how often they missed. But what if there was a loadout designed specifically around this feature?

The Hunter's Build challenges players to focus on precision by limiting them to just two weapons: The Punisher and the SR M1903. The goal is simple—make every shot count and achieve a 90% or higher accuracy rate by the end of each chapter.

8 The Classic Build

Revoke Nostalgia with Original RE4 Guns

Items in the Build: SG-09 R (handgun), TMP (sub-machine gun), W-870 (shotgun), Killer7 (magnum)
The Challenge: Avoiding new, flashy weapons.

The Resident Evil 4 remake introduced some exciting new weapons, like the Bolt Thrower and CQBR. However, for hardcore fans of the series, nothing compares to the nostalgia of firing Leon’s original guns. That’s where the Classic Build comes in.

leon in resident evil 4 remake holding a handgun.

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This loadout features the most iconic weapons from the original Resident Evil 4: the Silver Ghost, TMP, W-870, and Killer7. It’s also a versatile setup, offering reliable options for close- to mid-range combat. (Players can even add the SR M1903 for long-distance zombie sniping if they prefer.)

7 The Crowd-Control Build

Keep the Filthy Zombies Away

Items in the Build: Striker (shotgun), Chicago Sweeper (sub-machine gun), The Handcannon (magnum), the Primal Knife (melee), and Deer Antlers (accessory).
The Challenge: Getting no damage.

Being ambushed by a horde of zombies is an inevitable part of survival horror games. In the Resident Evil 4 remake, players face this challenge early on when they must fend off a group of villagers and a chainsaw-wielding enemy. For hardcore fans, this intense scenario can be further amplified with a Crowd-Control Build, which focuses on manipulating the movement and positioning of enemies, pushing them away from Leon and Ashley.

The Crowd-Control Build equips players with three pushback-heavy guns: the Striker, Handcannon, and Chicago Sweeper. The key is to use these weapons to keep enemies at a distance and under control. Additionally, the Deer Antler-Primal Knife combo provides a powerful melee option if any foes manage to break through the line and get too close.

6 The Demon Slayer Build

Call Out the Big Ones

Items in the Build: Red9 (handgun), Killer7 (magnum), Riot Gun (shotgun), Stingray (assault rifle)
The Challenge: Playing in Professional mode.

Boss fights are pivotal moments in the Resident Evil 4 remake, designed to be intense and challenging, especially compared to the original game's more forgiving nature. Whether the remake has successfully heightened these encounters is up for debate. Regardless, players can raise the stakes themselves with an accuracy- and firepower-focused build.

The Demon Slayer build challenges players to confront bosses using only standard weapons, such as the Red9 and Killer7. While these guns are powerful, they demand high accuracy—something hard to achieve in the game's tougher difficulty levels. To push the challenge even further, it's recommended to use this build in Professional mode, where Leon takes increased damage, leaving only a brief window to defeat each enemy.

5 The One-Shot Build

Pull the Trigger Once, Destroy Them All

Items in the Build: The infinite Rocket Launcher (RPG), The Handcannon (magnum)
The Challenge: One-shotting all enemies.

When Leon gets access to the infinite Rocket Launcher, it’s hard not to wonder: what if he just kept firing it at every enemy, all the way to the final boss? That’s the essence of the One-Shot build. Players who haven’t tried beating Resident Evil 4 with the infinite Rocket Launcher are missing out on countless hilarious moments—especially when a supposedly intimidating boss starts to attack Leon after a long, dramatic monologue. The payoff is that they’re instantly obliterated the moment Leon pulls the trigger, and it never stops being satisfying.

The One-Shot build also includes the Handcannon as a backup weapon for situations where firing a rocket launcher isn’t practical. For instance, in tight spaces, using rockets can be risky, as the blast could damage Leon and chip away at his health.

4 The Infinite Handgun Build

Never Run Out of Ammo Again

Items in the Build: Cat Ears (accessory), the Primal Knife (melee), and any pistol
The Challenge: Beating the game with a handgun.

One of the most intriguing accessories in the Resident Evil 4 remake is the Cat Ears. When Leon equips this item, he gains infinite ammo for all his weapons—except for the Bolt Thrower and Rocket Launcher. Now, picture combining this accessory with a fully upgraded, indestructible Primal Knife: Leon would become virtually unstoppable.

leon s kennedy in resident evil 4 remake.

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However, having unlimited ammo can make the game overly easy and may detract from the challenge. To maintain a sense of difficulty, the Infinite Handgun build restricts players to using only pistols. They can choose from any of the six handguns available in the Resident Evil 4 remake, aiming to complete the entire campaign without relying on any other weapon types.

3 The ‘Leon, the Professional’ Build

Counter Every Creature with an All-purpose Loadout

Items in the Build: Blacktail (handgun), LE5 with the biosensor scope (sub-machine gun), Riot Gun (shotgun), Stingray (assault rifle), Broken Butterfly (magnum)
The Challenge: Beating the game with an S+ rank in Professional mode.

The rank requirements in the Resident Evil 4 remake might seem intimidating at first, but for veteran players, they offer an exciting challenge. Achieving an S+ rank on Professional mode is one of the game’s toughest accomplishments, inspiring players to craft exclusive builds for this objective. And the “Leon, the Professional” is one such loadout.

The "Leon, the Professional" build takes advantage of the Resident Evil 4 remake’s most versatile weapons to create a counter for every enemy type. The Blacktail handles regular foes, the LE5 with a thermal scope is perfect for Regeneradors, the Riot Gun deals with transformed and shielded enemies, the Stingray targets projectile throwers, and the Broken Butterfly is reserved for bosses. The real fun of this loadout is that it keeps the game challenging across all difficulty levels without making enemies feel weak or underpowered.

2 The Untouchables Build

Become Invincible

Items in the Build: Chicken Hat (accessory), Ashley’s Armor (apparel), the Infinite Rocket Launcher (RPG), Chicago Sweeper (sub-machine gun)
The Challenge: Beating the game in one sitting.

With its 12- to 15-hour campaign, the Resident Evil 4 remake isn’t a game that players can easily finish in one sitting. However, the Untouchables build offers a way to complete all sixteen chapters in under five hours. This loadout makes both Leon and Ashley nearly invincible, thanks to two key items: the Chicken Hat and Ashley’s Armor.

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For players seeking an easy, no-hit playthrough, the Untouchables build is perfect. The Chicken Hat reduces melee damage taken by Leon, boosting his durability, while Ashley’s Armor prevents her from being killed or kidnapped. Combined with the infinite Rocket Launcher and Chicago Sweeper, the Untouchables loadout allows players to tear through enemies without taking damage, making for a breezy, unstoppable run.

1 The Melee Build

Play the RE4 Remake Like It’s an Archery Competition

Items in the Build: The Bolt Thrower (special weapon), the Primal Knife (melee), the Wolf Tail (accessory)
The Challenge: Beating the game with no ammo.

The most unique build to experiment with in the Resident Evil 4 remake is a melee loadout centered around the new Bolt Thrower. The challenge lies in completing the game using the Bolt Thrower's limited arrows, which can be retrieved after firing. What makes the Melee build so intriguing is how it completely transforms the gameplay. Using this weapon creates a fresh experience but also introduces a significant challenge, especially on higher difficulty levels.

As a backup, the Primal Knife and Wolf Tail are essential. They allow players to parry melee attacks, counter projectiles, and handle close-range kills. For maximum effectiveness, players are advised to fully upgrade the Primal Knife, making it indestructible for this demanding build.