How to Get More Plasmium Phial Reserves in Silksong

Quests in Hollow Knight: Silksong are requests that players can find either on the quest board in specific areas or through NPCs. One of these quests is the Advanced Alchemy quest, which starts during the third act of the game inside Wormways. Accessing the area will require a Simple Key, which players can get in different locations throughout Pharloom and the Citadel.

The guide below offers a walkthrough of the entire quest, along with a secret boss encounter that players can engage in inside the Wormways in Hollow Knight: Silksong.

Hollow Knight: Silksong - Interactive Map (Pharloom)

Our interactive map for Pharloom in Hollow Knight: Silksong. All the skills, tools, benches, and more found in the game.

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By The Best War Games Staff

Advanced Alchemy Quest Guide in Silksong

After completing the Alchemist’s Assistance quest in Act 1 or 2, players can revisit Alchemist Zylotol, who looks very different from the last time. This is because the Alchemist is trying to become a source of the Plasmium itself. You can refill your Plasmium reserve if you want for Rosaries, and after that, he will ask you to gather the Plasmified Blood from the creatures using the Needle Phial, which he will give you.

Extracting the Plasmified Blood in Silksong

Head down from the NPC’s location, and you will come across two enemy types inside the area. One of them is a digging enemy that can spit and charge at you, while the other is stuck on the ceiling and spits from a distance. To complete the quest, equip the Needle Phial and charge it at one of the enemies. When you hear the click sound, you can release the button, and you will extract the blood, killing the creatures in the process.

You have to do this a total of 10 times, after which you can go back to the Alchemist and hand over the items so that the wish is completed, and he will reward you with a Plasmium Gland. This item allows you to craft new Plasmium Phial without needing reserves.

Players can use the Plasmium Phials to increase their maximum health temporarily and refresh their tools using the Architect Crest up bind ability. This will allow them to increase their health further, but after a certain amount of mask shards, the health bar will turn blue, and players will be able to passively regenerate health.

Before leaving the area, players can go down to the bottom left of Wormways, where they will find a breakable wall on the left, which leads to a Secret boss encounter, which should be easy depending on what tools you have equipped.

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