While exploring the world of The Legend of Zelda: Tears of the Kingdom, players will need to search high and low to locate all the shrines. The Isisim Shrine is a shrine literally buried beneath the caves of the Eldin region waiting for players to unearth it.
Isisim Shrine Location in TotK
Players can find the Isisim Shrine in Tears of the Kingdom just east of the YunoboCo HQ at the foot of Death Mountain.
The fastest route to the shrine is to begin at the Marakugac Shrine in Goron City and travel directly north. The shrine itself is inside the YunoboCo HQ East Cave that can be entered around the coordinates 1762, 2830, 0399.
The entrance to the cave is blocked by marbled red rocks that can only be broken with Yunobo's Power of Fire. Players will need to have progressed to a certain point in the main quest "Yunobo of Goron City" to obtain this ability.
Inside the cave, Link will be subjected to extreme heat and a couple of Horriblins, so it is wise to be prepared.
Following the cave deeper and to the right, players will find a large pile of breakable rocks with the tip of the shrine poking out of the top.
Players can break their way through the rocks using any method they like to reach the Isisim Shrine buried below.
Isisim Shrine Walkthrough
The shrine's challenge "Proving Grounds: In Reverse" challenges players to fight through several constructs using only the equipment provided. At the start of the room, players can find a shield and a few weapons.
The theme of the challenge encourages the use of Link's Recall ability to reverse the direction of the gears in order to reach higher sections of the shrine. There are also several Zonai Time Bombs that the constructs will throw at the player that can be reversed back at them.
There are two different gears that players can use to ascend to the higher platforms to defeat the five constructs scattered throughout.
The time bombs can also be used to break the stone blocks within the shrine.
Doing so can reveal useful objects to fuse to Link's weapons and assist in combat.
After successfully defeating all enemies in the shrine, Link's equipment will be returned and the final room will be unlocked. There, the player can claim a 
Magic Rod from the chest and a Light of Blessing from the statue.
The Legend of Zelda: Tears of the Kingdom is available for the Nintendo Switch.